Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A
Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A
About this item
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Author / Creator
Yang, Chen , Zhao, Xinhao , Sun, Dakang , Yang, Leilei , Chong, Chang , Pan, Yu , Chi, Xiumei , Gao, Yanhang , Wang, Moli , Shi, Xiaodong , Sun, Haibo , Lv, Juan , Gao, Yuanda , Zhong, Jin , Niu, Junqi and Sun, Bing
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
TRIM22, a tripartite-motif (TRIM) protein, is upregulated upon interferon alpha (IFNα) administration to hepatitis C virus (HCV)-infected patients. However, the physiological role of TRIM22 upregulation remains unclear. Here, we describe a potential antiviral function of TRIM22's targeting of the HCV NS5A protein. NS5A is important for HCV replicat...
Alternative Titles
Full title
Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4711679
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4711679
Other Identifiers
ISSN
1672-7681
E-ISSN
2042-0226
DOI
10.1038/cmi.2014.131
