Systematic humanization of yeast genes reveals conserved functions and genetic modularity
Systematic humanization of yeast genes reveals conserved functions and genetic modularity
About this item
Full title
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Publisher
Washington: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington: American Association for the Advancement of Science
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Scope and Contents
Contents
To determine whether genes retain ancestral functions over a billion years of evolution and to identify principles of deep evolutionary divergence, we replaced 414 essential yeast genes with their human orthologs, assaying for complementation of lethal growth defects upon loss of the yeast genes. Nearly half (47%) of the yeast genes could be succes...
Alternative Titles
Full title
Systematic humanization of yeast genes reveals conserved functions and genetic modularity
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4718922
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4718922
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaa0769
