Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contrary to previous findings, this study finds that ablation of microglia, the resident macrophages of the brain, does not affect amyloid plaque or neuritic pathology in two mouse models of Alzheimer's disease.
In Alzheimer's disease, microglia cluster around β-amyloid deposits, suggesting that these cells are important for amyloid plaque forma...
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Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4721582
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4721582
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.2432
