NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In mouse embryonic stem cells converted to an epiblast fate
in vitro
—a state in which the cells can also gain germ cell fate if exposed to the signalling molecule BMP4—the sole expression of the transcription factor NANOG is shown to be sufficient to induce germ cell fate, in the absence of BMP4.
The role of
Nanog
in germ cells
T...
Alternative Titles
Full title
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4724940
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4724940
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature16480
