SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest...
SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Cranial neural crest cells (CNCCs) delaminate from embryonic neural folds and migrate to pharyngeal arches, which give rise to most mid-facial structures. CNCC dysfunction plays a prominent role in the etiology of orofacial clefts, a frequent birth malformation. Heterozygous mutations in
SPECC1L
have been identified in patients with atypical...
Alternative Titles
Full title
SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4726231
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4726231
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep17735
