TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL
TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL
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Author / Creator
Thébault, Stéphanie , Agez, Morgane , Chi, Xiaoke , Stojko, Johann , Cura, Vincent , Telerman, Stéphanie B. , Maillet, Laurent , Gautier, Fabien , Billas-Massobrio, Isabelle , Birck, Catherine , Troffer-Charlier, Nathalie , Karafin, Teele , Honoré, Joane , Senff-Ribeiro, Andrea , Montessuit, Sylvie , Johnson, Christopher M. , Juin, Philippe , Cianférani, Sarah , Martinou, Jean-Claude , Andrews, David W. , Amson, Robert , Telerman, Adam and Cavarelli, Jean
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Translationally Controlled Tumor Protein (TCTP) is anti-apoptotic, key in development and cancer, however without the typical Bcl2 family members’ structure. Here we report that TCTP contains a BH3-like domain and forms heterocomplexes with Bcl-xL. The crystal structure of a Bcl-xL deletion variant-TCTP
11–31
complex reveals that TCTP refolds...
Alternative Titles
Full title
TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL
Authors, Artists and Contributors
Author / Creator
Agez, Morgane
Chi, Xiaoke
Stojko, Johann
Cura, Vincent
Telerman, Stéphanie B.
Maillet, Laurent
Gautier, Fabien
Billas-Massobrio, Isabelle
Birck, Catherine
Troffer-Charlier, Nathalie
Karafin, Teele
Honoré, Joane
Senff-Ribeiro, Andrea
Montessuit, Sylvie
Johnson, Christopher M.
Juin, Philippe
Cianférani, Sarah
Martinou, Jean-Claude
Andrews, David W.
Amson, Robert
Telerman, Adam
Cavarelli, Jean
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4728560
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4728560
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep19725
