Robust enumeration of cell subsets from tissue expression profiles
Robust enumeration of cell subsets from tissue expression profiles
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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A computational method to identify cell types within a complex tissue, based on analysis of gene expression profiles, is described in this paper.
We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with respect to noise, unknown mixture content and closely related cell types. CIBERSORT should enable large-scale analysis of RNA mixtures for cellular biomarkers and therapeutic targets (
http://cibersort.stanford.edu/
)....
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Robust enumeration of cell subsets from tissue expression profiles
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4739640
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4739640
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/nmeth.3337
