Targeting IL-17A in multiple myeloma: a potential novel therapeutic approach in myeloma
Targeting IL-17A in multiple myeloma: a potential novel therapeutic approach in myeloma
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Author / Creator
Prabhala, R H , Fulciniti, M , Pelluru, D , Rashid, N , Nigroiu, A , Nanjappa, P , Pai, C , Lee, S , Prabhala, N S , Bandi, R L , Smith, R , Lazo-Kallanian, S B , Valet, S , Raje, N , Gold, J S , Richardson, P G , Daley, J F , Anderson, K C , Ettenberg, S A , Di Padova, F and Munshi, N C
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
We have previously demonstrated that interleukin-17A (IL-17) producing T helper 17 cells are significantly elevated in blood and bone marrow (BM) in multiple myeloma (MM) and IL-17A promotes MM cell growth via the expression of IL-17 receptor. In this study, we evaluated anti-human IL-17A human monoclonal antibody (mAb), AIN457 in MM. We observe si...
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Full title
Targeting IL-17A in multiple myeloma: a potential novel therapeutic approach in myeloma
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4740263
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4740263
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2015.228
