A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
About this item
Full title
Author / Creator
Stuckey, Jacob I , Dickson, Bradley M , Cheng, Nancy , Liu, Yanli , Norris, Jacqueline L , Cholensky, Stephanie H , Tempel, Wolfram , Qin, Su , Huber, Katherine G , Sagum, Cari , Black, Karynne , Li, Fengling , Huang, Xi-Ping , Roth, Bryan L , Baughman, Brandi M , Senisterra, Guillermo , Pattenden, Samantha G , Vedadi, Masoud , Brown, Peter J , Bedford, Mark T , Min, Jinrong , Arrowsmith, Cheryl H , James, Lindsey I and Frye, Stephen V
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Chromodomains in chromatin-associated proteins act as ‘readers’ of methylated lysines within histones. Structural and computational design led to the identification of UNC3866, a potent, cell-active peptide-based inhibitor of the methyllysine reading functions of CBX and CDY chromodomains.
We report the design and characterization of UNC3866, a...
Alternative Titles
Full title
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
Authors, Artists and Contributors
Author / Creator
Dickson, Bradley M
Cheng, Nancy
Liu, Yanli
Norris, Jacqueline L
Cholensky, Stephanie H
Tempel, Wolfram
Qin, Su
Huber, Katherine G
Sagum, Cari
Black, Karynne
Li, Fengling
Huang, Xi-Ping
Roth, Bryan L
Baughman, Brandi M
Senisterra, Guillermo
Pattenden, Samantha G
Vedadi, Masoud
Brown, Peter J
Bedford, Mark T
Min, Jinrong
Arrowsmith, Cheryl H
James, Lindsey I
Frye, Stephen V
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4755828
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4755828
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.2007
