Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9
Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Chromosomal translocation is the most common form of chromosomal abnormality and is often associated with congenital genetic disorders, infertility and cancers. The lack of cellular and animal models for chromosomal translocations, however, has hampered our ability to understand the underlying disease mechanisms and to develop new therapies. Here,...
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Full title
Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4761995
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4761995
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep21918
