Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis...
Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling
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Author / Creator
Feng, Bo , Tang, Yangshun , Chen, Bin , Xu, Cenglin , Wang, Yi , Dai, Yunjian , Wu, Dengchang , Zhu, Junmin , Wang, Shuang , Zhou, Yudong , Shi, Liyun , Hu, Weiwei , Zhang, Xia and Chen, Zhong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critical time window. Postnatal administered IL-1β alone...
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Full title
Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4763292
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4763292
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep21931
