De novo DNA methylation drives 5hmC accumulation in mouse zygotes
De novo DNA methylation drives 5hmC accumulation in mouse zygotes
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Using ultrasensitive mass spectrometry of wild-type and mutant early mouse zygotes, Hajkova and colleagues show that 5mC loss and 5hmC accumulation are uncoupled during zygotic epigenetic reprogramming.
Zygotic epigenetic reprogramming entails genome-wide DNA demethylation that is accompanied by Tet methylcytosine dioxygenase 3 (Tet3)-driven oxi...
Alternative Titles
Full title
De novo DNA methylation drives 5hmC accumulation in mouse zygotes
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4765106
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4765106
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3296
