An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma
About this item
Full title
Author / Creator
Drier, Yotam , Cotton, Matthew J , Williamson, Kaylyn E , Gillespie, Shawn M , Ryan, Russell J H , Kluk, Michael J , Carey, Christopher D , Rodig, Scott J , Sholl, Lynette M , Afrogheh, Amir H , Faquin, William C , Queimado, Lurdes , Qi, Jun , Wick, Michael J , El-Naggar, Adel K , Bradner, James E , Moskaluk, Christopher A , Aster, Jon C , Knoechel, Birgit and Bernstein, Bradley E
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Bradley Bernstein, Birgit Knoechel and colleagues identify super-enhancer translocations that drive overexpression of
MYB
in adenoid cystic carcinoma (ACC). They find that MYB binds to the translocated enhancers and to other active enhancers that drive different regulatory programs in alternate cell lineages in ACC.
Translocation events ar...
Alternative Titles
Full title
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma
Authors, Artists and Contributors
Author / Creator
Cotton, Matthew J
Williamson, Kaylyn E
Gillespie, Shawn M
Ryan, Russell J H
Kluk, Michael J
Carey, Christopher D
Rodig, Scott J
Sholl, Lynette M
Afrogheh, Amir H
Faquin, William C
Queimado, Lurdes
Qi, Jun
Wick, Michael J
El-Naggar, Adel K
Bradner, James E
Moskaluk, Christopher A
Aster, Jon C
Knoechel, Birgit
Bernstein, Bradley E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4767593
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4767593
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/ng.3502
