Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
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Author / Creator
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Shaw, Alice T , Friboulet, Luc , Leshchiner, Ignaty , Gainor, Justin F , Bergqvist, Simon , Brooun, Alexei , Burke, Benjamin J , Deng, Ya-Li , Liu, Wei , Dardaei, Leila , Frias, Rosa L , Schultz, Kate R , Logan, Jennifer , James, Leonard P , Smeal, Tod , Timofeevski, Sergei , Katayama, Ryohei , Iafrate, A. John , Le, Long , McTigue, Michele , Getz, Gad , Johnson, Ted W and Engelman, Jeffrey A
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
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Publication information
Publisher
United States: Massachusetts Medical Society
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More information
Scope and Contents
Contents
A resistance mutation (C1156Y) developed in a woman with anaplastic lymphoma kinase (
ALK
)-rearranged lung cancer who had a response to crizotinib. She then acquired resistance to lorlatinib. A lorlatinib resistance mutation (L1198F) led to resensitization to crizotinib.
Small-molecule tyrosine kinase inhibitors are standard therapies for...
Alternative Titles
Full title
Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
Authors, Artists and Contributors
Author / Creator
Shaw, Alice T
Friboulet, Luc
Leshchiner, Ignaty
Gainor, Justin F
Bergqvist, Simon
Brooun, Alexei
Burke, Benjamin J
Deng, Ya-Li
Liu, Wei
Dardaei, Leila
Frias, Rosa L
Schultz, Kate R
Logan, Jennifer
James, Leonard P
Smeal, Tod
Timofeevski, Sergei
Katayama, Ryohei
Iafrate, A. John
Le, Long
McTigue, Michele
Getz, Gad
Johnson, Ted W
Engelman, Jeffrey A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4773904
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4773904
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1508887
