Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism
About this item
Full title
Author / Creator
Oldridge, Derek A. , Wood, Andrew C. , Weichert-Leahey, Nina , Crimmins, Ian , Sussman, Robyn , Winter, Cynthia , McDaniel, Lee D. , Diamond, Maura , Hart, Lori S. , Zhu, Shizhen , Durbin, Adam D. , Abraham, Brian J. , Anders, Lars , Tian, Lifeng , Zhang, Shile , Wei, Jun S. , Khan, Javed , Bramlett, Kelli , Rahman, Nazneen , Capasso, Mario , Iolascon, Achille , Gerhard, Daniela S. , Guidry Auvil, Jaime M. , Young, Richard A. , Hakonarson, Hakon , Diskin, Sharon J. , Thomas Look, A. and Maris, John M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A causal variant is identified at the
LMO1
oncogene locus that drives the genetic association of
LMO1
with neuroblastoma susceptibility; the causal SNP disrupts a GATA transcription factor binding site within a tissue-specific super-enhancer element in the first intron of
LMO1
, thereby affecting
LMO1
expression.
LMO1
...
Alternative Titles
Full title
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism
Authors, Artists and Contributors
Author / Creator
Wood, Andrew C.
Weichert-Leahey, Nina
Crimmins, Ian
Sussman, Robyn
Winter, Cynthia
McDaniel, Lee D.
Diamond, Maura
Hart, Lori S.
Zhu, Shizhen
Durbin, Adam D.
Abraham, Brian J.
Anders, Lars
Tian, Lifeng
Zhang, Shile
Wei, Jun S.
Khan, Javed
Bramlett, Kelli
Rahman, Nazneen
Capasso, Mario
Iolascon, Achille
Gerhard, Daniela S.
Guidry Auvil, Jaime M.
Young, Richard A.
Hakonarson, Hakon
Diskin, Sharon J.
Thomas Look, A.
Maris, John M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4775078
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4775078
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature15540
