Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma
Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Background:
Multiple myeloma (MM) is an incurable clonal plasma cell malignancy. The constitutive expression of HIF-1
α
in MM suggests that inhibition of HIF-1
α
-mediated transcription represents an interesting target in MM.
Methods:
As p300 is a crucial co-activator of hypoxia-inducible transcription, disrupting the complex H...
Alternative Titles
Full title
Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4782210
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4782210
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/bjc.2016.20
