Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I...
Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1
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Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Aristolochic acid I (AAI) is a plant drug found in Aristolochia species that causes aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is activated via nitroreduction producing genotoxic N-hydroxyaristolactam, which forms DNA adducts. The major enzymes responsible for the reductive bioactivat...
Alternative Titles
Full title
Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4783945
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4783945
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms17020213
