A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
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Author / Creator
Green, Eric M. , Wakimoto, Hiroko , Anderson, Robert L. , Evanchik, Marc J. , Gorham, Joshua M. , Harrison, Brooke C. , Henze, Marcus , Kawas, Raja , Oslob, Johan D. , Rodriguez, Hector M. , Song, Yonghong , Wan, William , Leinwand, Leslie A. , Spudich, James A. , McDowell, Robert S. , Seidman, J. G. and Seidman, Christine E.
Publisher
United States: American Association for the Advancement of Science
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Language
English
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United States: American Association for the Advancement of Science
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Contents
Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be caused by mutations in sarcomere proteins. Clinical diagnosis depends on an abnormal thickening of the heart, but the earliest signs of disease are hyperdynamic contraction and impaired relaxation. Whereas some in vitro studies of power generation by mutant and wi...
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Full title
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4784435
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4784435
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aad3456
