Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6
Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Mig6 phosphorylation at two consecutive tyrosines induces rearrangements that lead to Mig6 sticking to and inhibiting the same EGFR that catalyzed its phosphorylation. This mechanism may serve as a basis for inhibition of oncogenic EGFR variants.
Mig6 is a feedback inhibitor that directly binds, inhibits and drives internalization of ErbB-family...
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Full title
Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4790445
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4790445
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3074
