Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
About this item
Full title
Author / Creator
Huang, Xi-Ping , Karpiak, Joel , Kroeze, Wesley K. , Zhu, Hu , Chen, Xin , Moy, Sheryl S. , Saddoris, Kara A. , Nikolova, Viktoriya D. , Farrell, Martilias S. , Wang, Sheng , Mangano, Thomas J. , Deshpande, Deepak A. , Jiang, Alice , Penn, Raymond B. , Jin, Jian , Koller, Beverly H. , Kenakin, Terry , Shoichet, Brian K. and Roth, Bryan L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
At least 120 non-olfactory G-protein-coupled receptors in the human genome are ‘orphans’ for which endogenous ligands are unknown, and many have no selective ligands, hindering the determination of their biological functions and clinical relevance. Among these is GPR68, a proton receptor that lacks small molecule modulators for probing its biology....
Alternative Titles
Full title
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
Authors, Artists and Contributors
Author / Creator
Karpiak, Joel
Kroeze, Wesley K.
Zhu, Hu
Chen, Xin
Moy, Sheryl S.
Saddoris, Kara A.
Nikolova, Viktoriya D.
Farrell, Martilias S.
Wang, Sheng
Mangano, Thomas J.
Deshpande, Deepak A.
Jiang, Alice
Penn, Raymond B.
Jin, Jian
Koller, Beverly H.
Kenakin, Terry
Shoichet, Brian K.
Roth, Bryan L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4796946
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4796946
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature15699
