Novel genomic island modifies DNA with 7-deazaguanine derivatives
Novel genomic island modifies DNA with 7-deazaguanine derivatives
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Author / Creator
Thiaville, Jennifer J. , Kellner, Stefanie M. , Yuan, Yifeng , Hutinet, Geoffrey , Thiaville, Patrick C. , Jumpathong, Watthanachai , Mohapatra, Susovan , Brochier-Armanet, Celine , Letarov, Andrey V. , Hillebrand, Roman , Malik, Chanchal K. , Rizzo, Carmelo J. , Dedon, Peter C. and de Crécy-Lagard, Valérie
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The discovery of ∼20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ₀) synthesis and DNA metabolism genes, led to the hypothesis that 7-deazaguanine derivatives are inserted in DNA. This was established by detecting 2′-deoxy-preQ₀ and 2′-deoxy-7-amido-7-...
Alternative Titles
Full title
Novel genomic island modifies DNA with 7-deazaguanine derivatives
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4801273
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4801273
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1518570113
