Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the ad...
Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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United States: National Academy of Sciences
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Contents
Spermatogonial stem cells (SSCs) fuel the production of male germ cells but the mechanisms behind SSC self-renewal, proliferation, and differentiation are still poorly understood. Using the Wnt target gene Axin2 and genetic lineage-tracing experiments, we found that undifferentiated spermatogonia, comprising SSCs and transit amplifying progenitor c...
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Full title
Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4801309
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4801309
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1601461113
