Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states
Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The anti-diabetic drug, metformin, exerts its action through AMP-activated protein kinase (AMPK), and Sirtuin (
Sirt1
) signaling. Insulin-like growth factor (IGF)-binding protein 2 (IGFBP-2) prevents IGF-1 binding to its receptors, thereby contributing to modulate insulin sensitivity. In this study, we demonstrate that metformin upregulates<...
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Full title
Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4806307
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4806307
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep23665