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Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states

Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4806307

Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states

About this item

Full title

Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2016-03, Vol.6 (1), p.23665, Article 23665

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The anti-diabetic drug, metformin, exerts its action through AMP-activated protein kinase (AMPK), and Sirtuin (
Sirt1
) signaling. Insulin-like growth factor (IGF)-binding protein 2 (IGFBP-2) prevents IGF-1 binding to its receptors, thereby contributing to modulate insulin sensitivity. In this study, we demonstrate that metformin upregulates<...

Alternative Titles

Full title

Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4806307

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4806307

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/srep23665

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