Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
About this item
Full title
Author / Creator
Mayer-Barber, Katrin D. , Andrade, Bruno B. , Oland, Sandra D. , Amaral, Eduardo P. , Barber, Daniel L. , Gonzales, Jacqueline , Derrick, Steven C. , Shi, Ruiru , Kumar, Nathella Pavan , Wei, Wang , Yuan, Xing , Zhang, Guolong , Cai, Ying , Babu, Subash , Catalfamo, Marta , Salazar, Andres M. , Via, Laura E. , Barry III, Clifton E. and Sher, Alan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Active tuberculosis has been linked to excessive type I interferon induction whereas interleukin-1 may have protective effects; here it is shown that interleukin-1 enhances the production of prostaglandin E2, which helps contain the pathogen while also suppressing detrimental type I interferon.
TB treatment targets innate immunity
Tuberculosi...
Alternative Titles
Full title
Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
Authors, Artists and Contributors
Author / Creator
Andrade, Bruno B.
Oland, Sandra D.
Amaral, Eduardo P.
Barber, Daniel L.
Gonzales, Jacqueline
Derrick, Steven C.
Shi, Ruiru
Kumar, Nathella Pavan
Wei, Wang
Yuan, Xing
Zhang, Guolong
Cai, Ying
Babu, Subash
Catalfamo, Marta
Salazar, Andres M.
Via, Laura E.
Barry III, Clifton E.
Sher, Alan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4809146
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4809146
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature13489
