Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer
Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer
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Author / Creator
Chen, Ke , Zhang, Jing , Guo, Zhongqiang , Ma, Qin , Xu, Zhengzheng , Zhou, Yuanyuan , Xu, Ziying , Li, Zhongwu , Liu, Yiqiang , Ye, Xiongjun , Li, Xuesong , Yuan, Bifeng , Ke, Yuwen , He, Chuan , Zhou, Liqun , Liu, Jiang and Ci, Weimin
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Both 5-methylcytosine （5mC） and its oxidized form 5-hydroxymethylcytosine （5hmC） have been proposed to be involved in tumorigenesis. Because the readout of the broadly used 5mC mapping method, bisulfite sequencing （BS-seq）, is the sum of 5mC and 5hmC levels, the 5mC/5hmC patterns and relationship of these two modifications remain poorly understood....
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Full title
Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4816137
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4816137
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ISSN
1001-0602
E-ISSN
1748-7838
DOI
10.1038/cr.2015.150
