Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
About this item
Full title
Author / Creator
Zhang, Lin , Zhang, Siyuan , Yao, Jun , Lowery, Frank J. , Zhang, Qingling , Huang, Wen-Chien , Li, Ping , Li, Min , Wang, Xiao , Zhang, Chenyu , Wang, Hai , Ellis, Kenneth , Cheerathodi, Mujeeburahiman , McCarty, Joseph H. , Palmieri, Diane , Saunus, Jodi , Lakhani, Sunil , Huang, Suyun , Sahin, Aysegul A. , Aldape, Kenneth D. , Steeg, Patricia S. and Yu, Dihua
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Expression of the tumour suppressor PTEN in disseminated primary tumour cells is lost after tumour cells metastasize to the brain, with downregulation instigated by microRNAs from astrocytes, which are transferred from cell to cell by exosomes; these findings reveal the dynamic nature of metastatic cancer cells when adapting to a new tissue environ...
Alternative Titles
Full title
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Authors, Artists and Contributors
Author / Creator
Zhang, Siyuan
Yao, Jun
Lowery, Frank J.
Zhang, Qingling
Huang, Wen-Chien
Li, Ping
Li, Min
Wang, Xiao
Zhang, Chenyu
Wang, Hai
Ellis, Kenneth
Cheerathodi, Mujeeburahiman
McCarty, Joseph H.
Palmieri, Diane
Saunus, Jodi
Lakhani, Sunil
Huang, Suyun
Sahin, Aysegul A.
Aldape, Kenneth D.
Steeg, Patricia S.
Yu, Dihua
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4819404
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4819404
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature15376
