Inhibition of HSV-1 Replication by Gene Editing Strategy
Inhibition of HSV-1 Replication by Gene Editing Strategy
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
HSV-1 induced illness affects greater than 85% of adults worldwide with no permanent curative therapy. We used RNA-guided CRISPR/Cas9 gene editing to specifically target for deletion of DNA sequences of the HSV-1 genome that span the region directing expression of ICP0, a key viral protein that stimulates HSV-1 gene expression and replication. We f...
Alternative Titles
Full title
Inhibition of HSV-1 Replication by Gene Editing Strategy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4827394
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4827394
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep23146
