Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit
Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit
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Full title
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Epithelial tuft cells are shown to be the source of intestinal interleukin (IL)-25 that is required for activation of type 2 innate lymphoid cells (ILC2s), ILC2-regulated tuft and goblet cell expansion, and control of parasite infection.
Epithelial tuft cells in type 2 immunity
The 'weep-and-sweep' response to parasitic helminths and allergen...
Alternative Titles
Full title
Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4830391
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4830391
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature16161
