Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tubercu...
Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tuberculosis
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The transcriptional regulator PhoP is an essential virulence factor in
Mycobacterium tuberculosis
, and it presents a target for the development of new anti-tuberculosis drugs and attenuated tuberculosis vaccine strains. PhoP binds to DNA as a highly cooperative dimer by recognizing direct repeats of 7-bp motifs with a 4-bp spacer. To elucida...
Alternative Titles
Full title
Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tuberculosis
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4832192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4832192
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep24442
