The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology...
The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
E-52862 is a selective σ
1
R antagonist currently undergoing phase II clinical trials for neuropathic pain and represents a potential first-in-class analgesic. Here, we investigated the effect of single and repeated administration of E-52862 on different pain-related behaviours in several neuropathic pain models in rats: mechanical allodynia...
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The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4834548
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4834548
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep24591
