Deletions linked to TP53 loss drive cancer through p53-independent mechanisms
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms
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Author / Creator
Liu, Yu , Chen, Chong , Xu, Zhengmin , Scuoppo, Claudio , Rillahan, Cory D. , Gao, Jianjiong , Spitzer, Barbara , Bosbach, Benedikt , Kastenhuber, Edward R. , Baslan, Timour , Ackermann, Sarah , Cheng, Lihua , Wang, Qingguo , Niu, Ting , Schultz, Nikolaus , Levine, Ross L. , Mills, Alea A. and Lowe, Scott W.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Mutations disabling the
TP53
tumour suppressor gene represent the most frequent events in human cancer and typically occur through a two-hit mechanism involving a missense mutation in one allele and a ‘loss of heterozygosity’ deletion encompassing the other. While
TP53
missense mutations can also contribute gain-of-function activities t...
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Full title
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4836395
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4836395
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature17157
