Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals
Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals
About this item
Full title
Author / Creator
Publisher
New York: Springer US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer US
Subjects
More information
Scope and Contents
Contents
Purpose
DNA Ligase 4 (LIG4) is a key factor in the non-homologous end-joining (NHEJ) DNA double-strand break repair pathway needed for V(D)J recombination and the generation of the T cell receptor and immunoglobulin molecules. Defects in
LIG4
result in a variable syndrome of growth retardation, pancytopenia, combined immunodeficiency, cell...
Alternative Titles
Full title
Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4842108
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4842108
Other Identifiers
ISSN
0271-9142
E-ISSN
1573-2592
DOI
10.1007/s10875-016-0266-5
