USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites
USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The proteasome-associated enzyme USP14 regulates protein degradation by removing ubiquitin from proteins; here it is shown that USP14 removes ubiquitin chains from
in vitro
generated cyclin B conjugates en bloc and within milliseconds, before the proteasome has a chance to initiate degradation, and proceeds until a single chain remains.
US...
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Full title
USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4844788
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4844788
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature17433
