A single active catalytic site is sufficient to promote transport in P-glycoprotein
A single active catalytic site is sufficient to promote transport in P-glycoprotein
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
P-glycoprotein (Pgp) is an ABC transporter responsible for the ATP-dependent efflux of chemotherapeutic compounds from multidrug resistant cancer cells. Better understanding of the molecular mechanism of Pgp-mediated transport could promote rational drug design to circumvent multidrug resistance. By measuring drug binding affinity and reactivity to...
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Full title
A single active catalytic site is sufficient to promote transport in P-glycoprotein
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4846820
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4846820
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep24810
