Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
About this item
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Author / Creator
Schoenfelder, Stefan , Sugar, Robert , Dimond, Andrew , Javierre, Biola-Maria , Armstrong, Harry , Mifsud, Borbala , Dimitrova, Emilia , Matheson, Louise , Tavares-Cadete, Filipe , Furlan-Magaril, Mayra , Segonds-Pichon, Anne , Jurkowski, Wiktor , Wingett, Steven W , Tabbada, Kristina , Andrews, Simon , Herman, Bram , LeProust, Emily , Osborne, Cameron S , Koseki, Haruhiko , Fraser, Peter , Luscombe, Nicholas M and Elderkin, Sarah
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Sarah Elderkin and colleagues show that PRC1 acts as a master regulator of genome architecture in mouse embryonic stem cells by organizing genes in three-dimensional interaction networks. They find that the strongest spatial network is composed of the four
Hox
clusters and key early developmental transcription factor genes, and they propose t...
Alternative Titles
Full title
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
Authors, Artists and Contributors
Author / Creator
Sugar, Robert
Dimond, Andrew
Javierre, Biola-Maria
Armstrong, Harry
Mifsud, Borbala
Dimitrova, Emilia
Matheson, Louise
Tavares-Cadete, Filipe
Furlan-Magaril, Mayra
Segonds-Pichon, Anne
Jurkowski, Wiktor
Wingett, Steven W
Tabbada, Kristina
Andrews, Simon
Herman, Bram
LeProust, Emily
Osborne, Cameron S
Koseki, Haruhiko
Fraser, Peter
Luscombe, Nicholas M
Elderkin, Sarah
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4847639
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4847639
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3393
