NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exo...
NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exogenously applied oxidant
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Publisher
United States: Taylor & Francis
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Language
English
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United States: Taylor & Francis
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Reactive oxygen species (ROS) play an important role in causing neuronal death in a number of neurological disorders. We recently reported that ROS serve as a signal to activate neuronal apoptosis and axonal degeneration by activating ZNRF1 (zinc- and RING-finger 1), a ubiquitin ligase that targets AKT for proteasomal degradation in neurons. In the...
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Full title
NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exogenously applied oxidant
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4857788
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4857788
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ISSN
1942-0889
E-ISSN
1942-0889
DOI
10.1080/19420889.2016.1143575
