Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling
Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Gain of MEKK3 signalling is shown to cause cerebral cavernous malformations (CCMs) via activation of the target genes
Klf2
and
Klf4
; endothelial-specific loss of MEKK3, KLF2 or KLF4 prevents lesion formation and lethality in a mouse CCM model.
Genetic rescue of cerebral cavernous malformations
Mark Kahn and colleagues identify a...
Alternative Titles
Full title
Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4864035
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4864035
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature17178
