Universal allosteric mechanism for Gα activation by GPCRs
Universal allosteric mechanism for Gα activation by GPCRs
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
G protein-coupled receptors (GPCRs) allosterically activate heterotrimeric G proteins and trigger GDP release. Given that there are ∼800 human GPCRs and 16 different Gα genes, this raises the question of whether a universal allosteric mechanism governs Gα activation. Here we show that different GPCRs interact with and activate Gα proteins through a...
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Full title
Universal allosteric mechanism for Gα activation by GPCRs
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4866443
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4866443
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14663
