A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinic...
A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies
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Publisher
England: Nature Publishing Group
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English
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England: Nature Publishing Group
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Nociceptin/Orphanin FQ (N/OFQ) is an endogenous ligand of the N/OFQ peptide (NOP) receptor, which is a G protein-coupled receptor in brain regions associated with mood disorders. We used a novel, potent, and selective orally bioavailable antagonist, LY2940094, to test the hypothesis that blockade of NOP receptors would induce antidepressant effects...
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A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4869049
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4869049
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ISSN
0893-133X
E-ISSN
1740-634X
DOI
10.1038/npp.2015.348
