A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
To mediate the degradation of biomacromolecules, lysosomes must traffic towards cargo-carrying vesicles for subsequent membrane fusion or fission. Mutations of the lysosomal Ca
2+
channel TRPML1 cause lysosomal storage disease (LSD) characterized by disordered lysosomal membrane trafficking in cells. Here we show that TRPML1 activity is requi...
Alternative Titles
Full title
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4871318
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4871318
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3324
