Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
CRISPR/Cas9 DNA editing creates a double-stranded break in the target DNA, which can frequently generate random insertion or deletion of bases (indels); a new genome editing approach combining Cas9 with a cytidine deaminase is described here, which corrects point mutations more efficiently than canonical Cas9, while avoiding double-stranded breaks...
Alternative Titles
Full title
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4873371
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4873371
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature17946
