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Structural insights into inhibition of lipid I production in bacterial cell wall synthesis

Structural insights into inhibition of lipid I production in bacterial cell wall synthesis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4882255

Structural insights into inhibition of lipid I production in bacterial cell wall synthesis

About this item

Full title

Structural insights into inhibition of lipid I production in bacterial cell wall synthesis

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2016-05, Vol.533 (7604), p.557-560

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

Subjects

Subjects and topics

More information

Scope and Contents

Contents

The crystal structure of the MraY enzyme from
Aquifex aeolicus
in complex with the naturally occurring nucleoside inhibitor muraymycin D2 (MD2) reveals that MraY undergoes a large conformational rearrangement near the active site after the binding of MD2, leading to the generation of a nucleoside-binding pocket and a peptide-binding site.
...

Alternative Titles

Full title

Structural insights into inhibition of lipid I production in bacterial cell wall synthesis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4882255

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4882255

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature17636

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