Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair.
DNA 5-methylcytosine is a dynamic epigenetic mark with important roles in develop...
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Full title
Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4894546
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4894546
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3151
