Design of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm ac...
Design of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
AR-23 is a melittin-related peptide with 23 residues. Like melittin, its high α-helical amphipathic structure results in strong bactericidal activity and cytotoxicity. In this study, a series of AR-23 analogues with low amphipathicity were designed by substitution of Ala1, Ala8 and Ile17 with positively charged residues (Arg or Lys) to study the ef...
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Full title
Design of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4897634
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4897634
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep27394
