Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
About this item
Full title
Author / Creator
Dewey, Frederick E , Gusarova, Viktoria , O’Dushlaine, Colm , Gottesman, Omri , Trejos, Jesus , Hunt, Charleen , Van Hout, Cristopher V , Habegger, Lukas , Buckler, David , Lai, Ka-Man V , Leader, Joseph B , Murray, Michael F , Ritchie, Marylyn D , Kirchner, H. Lester , Ledbetter, David H , Penn, John , Lopez, Alexander , Borecki, Ingrid B , Overton, John D , Reid, Jeffrey G , Carey, David J , Murphy, Andrew J , Yancopoulos, George D , Baras, Aris , Gromada, Jesper and Shuldiner, Alan R
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
This study showed an association of loss-of-function mutations in
ANGPTL4
with low triglyceride levels and protection against coronary artery disease. Inhibition of Angptl4 in mice and monkeys with a monoclonal antibody reduced triglyceride levels.
The level of serum triglycerides is, in part, heritable, and elevated levels are associated...
Alternative Titles
Full title
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
Authors, Artists and Contributors
Author / Creator
Gusarova, Viktoria
O’Dushlaine, Colm
Gottesman, Omri
Trejos, Jesus
Hunt, Charleen
Van Hout, Cristopher V
Habegger, Lukas
Buckler, David
Lai, Ka-Man V
Leader, Joseph B
Murray, Michael F
Ritchie, Marylyn D
Kirchner, H. Lester
Ledbetter, David H
Penn, John
Lopez, Alexander
Borecki, Ingrid B
Overton, John D
Reid, Jeffrey G
Carey, David J
Murphy, Andrew J
Yancopoulos, George D
Baras, Aris
Gromada, Jesper
Shuldiner, Alan R
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4900689
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4900689
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1510926
