Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice
Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Mutations or deletions of the maternal allele of the
UBE3A
gene cause Angelman syndrome (AS), a severe neurodevelopmental disorder. The paternal
UBE3A/Ube3a
allele becomes epigenetically silenced in most neurons during postnatal development in humans and mice; hence, loss of the maternal allele largely eliminates neuronal expression of...
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Full title
Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4910164
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4910164
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep28238
