Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells
Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells
About this item
Full title
Author / Creator
Abraham, Sheela A. , Hopcroft, Lisa E. M. , Carrick, Emma , Drotar, Mark E. , Dunn, Karen , Williamson, Andrew J. K. , Korfi, Koorosh , Baquero, Pablo , Park, Laura E. , Scott, Mary T. , Pellicano, Francesca , Pierce, Andrew , Copland, Mhairi , Nourse, Craig , Grimmond, Sean M. , Vetrie, David , Whetton, Anthony D. and Holyoake, Tessa L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR–ABL. Direct inhibition of BCR–ABL kinase has revolutionized disease management, but fails to eradicate leukaemic stem cells (LSCs), which maintain CML. LSCs are independent of BCR–ABL for survival, providing a rationale f...
Alternative Titles
Full title
Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells
Authors, Artists and Contributors
Author / Creator
Hopcroft, Lisa E. M.
Carrick, Emma
Drotar, Mark E.
Dunn, Karen
Williamson, Andrew J. K.
Korfi, Koorosh
Baquero, Pablo
Park, Laura E.
Scott, Mary T.
Pellicano, Francesca
Pierce, Andrew
Copland, Mhairi
Nourse, Craig
Grimmond, Sean M.
Vetrie, David
Whetton, Anthony D.
Holyoake, Tessa L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4913876
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4913876
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature18288
