Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen
Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen
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Cham: Springer International Publishing
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Language
English
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Cham: Springer International Publishing
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Introduction
Acetaminophen (paracetamol) is mainly metabolized via glucuronidation and sulphation, while the minor pathway through cytochrome P450 (CYP) 2E1 is held responsible for hepatotoxicity. In obese patients, CYP2E1 activity is reported to be induced, thereby potentially worsening the safety profile of acetaminophen. The aim of this study...
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Full title
Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4916199
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4916199
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ISSN
0312-5963
E-ISSN
1179-1926
DOI
10.1007/s40262-015-0357-0
