Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
About this item
Full title
Author / Creator
National Institutes of Health (NIH), Bethesda, MD (United States) , Kong, Rui , Xu, Kai , Zhou, Tongqing , Acharya, Priyamvada , Lemmin, Thomas , Liu, Kevin , Ozorowski, Gabriel , Soto, Cinque , Taft, Justin D. , Bailer, Robert T. , Cale, Evan M. , Chen, Lei , Choi, Chang W. , Chuang, Gwo-Yu , Doria-Rose, Nicole A. , Druz, Aliaksandr , Georgiev, Ivelin S. , Gorman, Jason , Huang, Jinghe , Joyce, M. Gordon , Louder, Mark K. , Ma, Xiaochu , McKee, Krisha , O'Dell, Sijy , Pancera, Marie , Yang, Yongping , Blanchard, Scott C. , Mothes, Walther , Burton, Dennis R. , Koff, Wayne C. , Connors, Mark , Ward, Andrew B. , Kwong, Peter D. and Mascola, John R.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
The HIV-1 fusion peptide, comprising 15 to 20 hydrophobic residues at the N terminus of the Env-gp41 subunit, is a critical component of the virus-cell entry machinery. Here, we report the identification of a neutralizing antibody, N123-VRC34.01, which targets the fusion peptide and blocks viral entry by inhibiting conformational changes in gp120 a...
Alternative Titles
Full title
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
Authors, Artists and Contributors
Author / Creator
Kong, Rui
Xu, Kai
Zhou, Tongqing
Acharya, Priyamvada
Lemmin, Thomas
Liu, Kevin
Ozorowski, Gabriel
Soto, Cinque
Taft, Justin D.
Bailer, Robert T.
Cale, Evan M.
Chen, Lei
Choi, Chang W.
Chuang, Gwo-Yu
Doria-Rose, Nicole A.
Druz, Aliaksandr
Georgiev, Ivelin S.
Gorman, Jason
Huang, Jinghe
Joyce, M. Gordon
Louder, Mark K.
Ma, Xiaochu
McKee, Krisha
O'Dell, Sijy
Pancera, Marie
Yang, Yongping
Blanchard, Scott C.
Mothes, Walther
Burton, Dennis R.
Koff, Wayne C.
Connors, Mark
Ward, Andrew B.
Kwong, Peter D.
Mascola, John R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4917739
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4917739
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aae0474
