Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration
Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Adducts of retinaldehyde (bisretinoids) form nonenzymatically in photoreceptor cells and accumulate in retinal pigment epithelial (RPE) cells as lipofuscin; these fluorophores are implicated in the pathogenesis of inherited and age-related macular degeneration (AMD). Here we demonstrate that bisretinoid photodegradation is ongoing in the eye. High-...
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Full title
Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4922174
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4922174
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1524774113
